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akari therapeutics plc (AKTX) Details

Akari Therapeutics, Plc, a clinical-stage biopharmaceutical company, focuses on the development and commercialization of treatments for a range of rare and orphan autoimmune and inflammatory diseases. Its lead product candidate is Coversin, a second-generation complement inhibitor that is in Phase II clinical trial for the treatment of autoimmune and inflammatory diseases, including paroxysmal nocturnal hemoglobinuria, guillain barré syndrome, and atypical hemolytic uremic syndrome. Akari Therapeutics, Plc is based in London, the United Kingdom.

13 Employees
Last Reported Date: 04/23/19

akari therapeutics plc (AKTX) Top Compensated Officers

COO, Director & Interim CEO
Total Annual Compensation: $520.8K
Executive Chairman
Total Annual Compensation: $318.3K
Chief Financial Officer
Total Annual Compensation: $343.7K
Compensation as of Fiscal Year 2018.
akari therapeutics plc
Akari Therapeutics, plc Announces Positive Initial Phase II Clinical Data from First Three of Bullous Pemphigoid Patients in an Ongoing Clinical Trial

Akari Therapeutics, Plc announced positive initial Phase II clinical data from the first three of bullous pemphigoid (BP) patients in an ongoing clinical trial. Bullous pemphigoid is a severe orphan inflammatory skin disease currently treated primarily with steroids and immunosuppressants which bring with them well known side effects. Treatment response and steroid potency varies significantly based on the severity of the disease, although flares and relapses frequently occur. In patients with bullous pemphigoid there is evidence that both terminal complement activation (C5) and the lipid mediator leukotriene B4 (LTB4) have a central role in driving the disease. Ex vivo data, from a recent study at Lubeck University, in BP patients showed a pronounced accumulation of LTB4 and C5 and its activation products in the inflamed skin of bullous pemphigoid disease patients. The Phase II trial for up to nine mild-to-moderate bullous pemphigoid patients is a six-week open-label single-arm study evaluating safety and with the main efficacy measure the Bullous Pemphigoid Disease Area Index (BPDAI) a frequently used evaluation of the extent and severity of the disease. Initial results from the first three patients showed that Nomacopan (Coversin), dosed daily subcutaneously, was well tolerated in three elderly patients (>65 years), and that there were no drug-related adverse events. Prior to treatment with Nomacopan (Coversin), two out of the three patients were already on topical corticosteroids (mometasone) while a third was naïve to steroid treatment. Steroids were reduced at weekly intervals so that by day 21 both patients were only treated with Nomacopan (Coversin). In the 7-11-day period prior to initiation on Nomacopan (Coversin), the two patients on steroids showed either no or minor improvement in their BPDAI global score (between 0% and 5%) and no improvement in blisters.

Akari Therapeutics, Plc Presents at H.C. Wainwright Global Life Sciences Conference, Apr-08-2019 11:10 AM

Akari Therapeutics, Plc Presents at H.C. Wainwright Global Life Sciences Conference, Apr-08-2019 11:10 AM. Venue: Grosvenor House A JW Marriot Hotel, London, United Kingdom.

Akari Therapeutics, plc Announces Successful Type B, Pre-IND Meeting with the Food and Drug Administration Regarding Proposed Pivotal Clinical Trial Program for Pediatric Hematopoietic Stem Cell Transplant-Related Thrombotic Microangiopathy (HSCT-TMA)

Akari Therapeutics, Plc announced that it had a successful Type B, pre-IND meeting with the Food and Drug Administration (FDA) regarding Akari’s proposed pivotal clinical trial program for pediatric hematopoietic stem cell transplant-related thrombotic microangiopathy (HSCT-TMA). HSCT-TMA is an orphan condition with an estimated fatality rate of more than 80% in children with the severe disease. A framework for the trial design was agreed to with the FDA in which the response to Coversin of selected, clinically meaningful treatment variables would be the primary endpoint in the proposed pivotal trial. These responder endpoints were based on work done by Sonata Jodele, M.D., a expert in treating pediatric HSCT-TMA.

 

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